COVID-19-associated diarrhea

نویسندگان

چکیده

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently emerged as a highly virulent pathogen that is known the causative agent of disease 2019 (COVID-19). Diarrhea common early symptom in significant proportion patients with SARS-CoV-2 infection. can infect and replicate esophageal cells enterocytes, leading to direct damage intestinal epithelium. The infection decreases level angiotensin-converting enzyme receptors, thereby altering composition gut microbiota. elicits cytokine storm, which contributes gastrointestinal inflammation. cytopathic effects SARS-CoV-2, dysbiosis, aberrant immune response result increased permeability, may exacerbate existing symptoms worsen prognosis. By exploring elements pathogenesis, several therapeutic options have for treatment COVID-19 patients, such biologics biotherapeutic agents. However, presence feces facilitate spread through fecal-oral transmission contaminate environment. Thus has important epidemiological significance. development new preventive necessary treat restrict this severe widespread more effectively. Therefore, we summarize key involved pathogenesis epidemiology COVID-19-associated diarrhea.

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ژورنال

عنوان ژورنال: World Journal of Gastroenterology

سال: 2021

ISSN: ['2219-2840', '1007-9327']

DOI: https://doi.org/10.3748/wjg.v27.i23.3208